Network analysis of large-scale ImmGen and Tabula Muris datasets highlights metabolic diversity of tissue mononuclear phagocytes. Gainullina A, Mogilenko DA, Huang LH, Todorov H, Narang V, Kim KW, Yng LS, Kent A, Jia B, Seddu K, Krchma K, Wu J, Crozat K, Tomasello E, Dress R, See P, Scott C, Gibbings S, Bajpai G, Desai JV, Maier B, This S, Wang P, Aguilar SV, Poupel L, Dussaud S, Zhou TA, Angeli V, Blander JM, Choi K, Dalod M, Dzhagalov I, Gautier EL, Jakubzick C, Lavine K, Lionakis MS, Paidassi H, Sieweke MH, Ginhoux F, Guilliams M, Benoist C, Merad M, Randolph GJ, Sergushichev A, Artyomov MN; ImmGen Consortium; Cell Rep. 2023 Jan 27;42(2):112046. doi: 10.1016/j.celrep.2023.112046. Link
IFN-stimulated metabolite transporter ENT3 facilitates viral genome release. Hsieh YT, Tsai TL, Huang SY, Heng JW, Huang YC, Tsai PY, Tu CC, Chao TL, Tsai YM, Chang PC, Lee CK, Yu GY, Chang SY, Dzhagalov IL; Hsu CL. EMBO Rep. 2023 Jan 18:e55286. doi: 10.15252/embr.202255286. Link
Protocol for standardized intrathymic injection in mice. Tsai TL, Tsai PY, Dzhagalov IL, Hsu CL; STAR Protoc. 2023 Jan 12;4(1):102010. doi: 10.1016/j.xpro.2022.102010. Link
Thymic macrophages consist of two populations with distinct localization and origin. Zhou TA, Hsu HP, Tu YH, Cheng HK, Lin CY, Chen NJ, Tsai JW, Robey EA, Huang HC, Hsu CL, Dzhagalov IL; Elife. 2022 Nov 30;11:e75148. doi: 10.7554/eLife.75148. Link
Heparin is required for the formation of granules in connective tissue mast cells. Herrera-Heredia SA, Hsu HP, Kao YC, Tsai YH, Yamaguchi Y, Roers A, Hsu CL, Dzhagalov IL; Front Immunol. 2022; Nov 09; 13:1000405. doi: 10.3389/fimmu.2022.1000405. Link
Multiomics reveal the central role of pentose phosphate pathway in resident thymic macrophages to cope with efferocytosis-associated stress. Tsai TL, Zhou TA, Hsieh YT, Wang JC, Cheng HK, Huang CH, Tsai PY, Fan HH, Feng HK, Huang YC, Lin CC, Lin CH, Lin CY, Dzhagalov IL, Hsu CL; Cell Rep. 2022; Jul 12; 40(2):111065. doi:10.1016/j.celrep.2022.111065. Link
Evaluation of Mitochondria Content and Function in Live Cells by Multicolor Flow Cytometric Analysis. Fan HH, Tsai TL, Dzhagalov IL, Hsu CL; Methods Mol Biol.2021;2276:203-213. doi: 10.1007/978-1-0716-1266-8_15 Link
Heparan sulfate is essential for thymus growth. Hsu HP, Chen YT, Chen YY, Lin CY, Chen PY, Liao SY, Lim CCY, Yamaguchi Y, Hsu CL, Dzhagalov IL; J Biol Chem. 2021 Feb 15:100419. doi: 10.1016/j.jbc.2021.100419. Link
Examination of Fas-Induced Apoptosis of Murine Thymocytes in Thymic Tissue Slices Reveals That Fas Is Dispensable for Negative Selection. Chu CF, Feng HK, Sun KH, Hsu CL, Dzhagalov IL; Front. Cell Dev. Biol. 8:586807. doi: 10.3389/fcell.2020.586807. Link
Vaccine adjuvant activity of a TLR4-activating synthetic glycolipid by promoting autophagy. Chou YJ, Lin CC, Dzhagalov IL, Chen NC, Lin CH, Lin CC, Chen ST, Chen KH, Fu SL. Sci Rep. 2020 May 21;10(1):8422. Doi: 10.1038/s41598-020-65422-1. Link
Testing the Efficiency and Kinetics of Negative Selection Using Thymic Slices. Zhou TA, Hsu CL, Dzhagalov IL. Methods Mol Biol. 2020;2111:205-219. doi: 10.1007/978-1-0716-0266-9_17. Link
A role for phagocytosis in inducing cell death during thymocyte negative selection. Kurd NS, Lutes LK, Yoon J, Chan SW, Dzhagalov IL, Hoover AR, Robey EA. Elife. 2019 Dec 23;8. pii: e48097. Link
Low human and murine Mcl-1 expression leads to a pro-apoptotic plaque phenotype enriched in giant-cells. Fontaine MAC, Westra MM, Bot I, Jin H, Franssen AJPM, Bot M, de Jager SCA, Dzhagalov I, He YW, van Vlijmen BJM, Gijbels MJJ, Reutelingsperger CP, van Berkel TJC, Sluimer JC, Temmerman L, Biessen EAL. Sci Rep. 2019 Oct 10;9(1):14547. doi: 10.1038/s41598-019-51020-3. Link
Metabolite Transporters—The Gatekeepers for T Cell Metabolism. Hsu C-L, Dzhagalov IL. Immunometabolism. 2019;1:e190012. https://doi.org/10.20900/immunometab20190012. Link
NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25. Chen ST, Chen L, Lin DS, Chen SY, Tsao YP, Guo H, Li FJ, Tseng WT, Tam JW, Chao CW, Brickey WJ, Dzhagalov I, Song MJ, Kang HR, Jung JU, Ting JP. Cell Host Microbe. 2019 Apr 10;25(4):602-616.e7. doi: 10.1016/j.chom.2019.02.013. Epub 2019 Mar 19. Link
Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells. Wei CW, Zhou TA, Dzhagalov IL, Hsu CL. J. Vis. Exp. 2019 Jan 8;(143), e58844, doi:10.3791/58844. Link
Equilibrative Nucleoside Transporter 3 Regulates T Cell Homeostasis by Coordinating Lysosomal Function with Nucleoside Availability. Wei CW, Lee CY, Lee DJ, Chu CF, Wang JC, Wang TC, Jane WN, Chang ZF, Leu CM, Dzhagalov IL, Hsu CL. Cell Rep. 2018 May 22; 23(8):2330-2341. doi: 10.1016/j.celrep.2018.04.077. Link